Formulari Ubat KKM (FUKKM)

# Generic Name MDC Category Indications Pres. Restrictions Dosage
31 Salbutamol 2mg/5ml Syrup R03CC02-183-L90-01-XXX B Asthma and other conditions associated with reversible airways obstruction None CHILD 2 - 6 years : 1 - 2 mg 3 - 4 times daily, 6 - 12 years : 2 mg 3 -4 times daily
32 Salbutamol 5mg/5ml Injection R03CC02-183-P30-02-XXX A i. Asthma and other conditions associated with reversible airways obstruction

ii. For prevention of uncomplicated premature labour		 None i. 500 mcg by SC/IM injection 4 hourly or 250 mcg by slow IV. If required, by IV infusion, initially 5 mcg/min adjusted according to response and heart rate, usually in the range 3 - 20 mcg/min

ii. Infusions containing 5 mg in 500ml (10 mcg/ml) at the rate of 10 - 45 mcg/min increased at intervals of 10 minutes until evidence of patient response as shown by reduction of strength, frequency or duration of contractions; maintain rate for 1 hour after contractions have stopped, then gradually reduce by 50% every 6 hours
33 Salmeterol 25mcg and Fluticasone Propionate 125mcg Inhalation R03AK06-989-A21-02-XXX A* Regular treatment of reversible obstructive airway diseases including asthma. None ADULT and CHILD more than 12 years : 1 - 2 puff twice daily.
CHILD over 4 years : 1 puff twice daily
34 Salmeterol 25mcg and Fluticasone Propionate 50mcg Inhalation R03AK06-989-A21-04-XXX A* Regular treatment of reversible obstructive airway diseases including asthma in children, where use of lower dose of a combination (bronchodilator and inhaled corticosteroids) is appropriate. Limited to paediatric population for the purpose of dose tapering CHILD more than 12 years : 2 puff twice daily.
CHILD over 4 years : 2 puff twice daily
No data on use for children aged under 4 years.
35 Salmeterol 50mcg & Fluticasone Propionate 250mcg Inhalation R03AK06-989-A21-01-XXX A*, A/KK Prescriber Category A*:
i) Treatment of COPD patients with a blood eosinophil count of 300 cells/microliter and more
ii) Treatment of COPD patients with blood eosinophil count of 100 cells/microliter and more with history of repeated exacerbation despite regular treatment with long-acting bronchodilators.

Prescriber Category A/KK:
- Regular treatment of reversible obstructive airways diseases including asthma.		 None ADULT and CHILD more than 12 years : 1 puff twice daily.
36 Salmeterol 50mcg and Fluticasone Propionate 500mcg Inhalation R03AK06-989-A21-06-XXX A*, A/KK Prescriber Category A*:
i) Treatment of COPD patients with a blood eosinophil count of 300 cells/microliter and more
ii) Treatment of COPD patients with blood eosinophil count of 100 cells/microliter and more with history of repeated exacerbation despite regular treatment with long-acting bronchodilators.

Prescriber Category A/KK:
- Regular treatment of reversible obstructive airways diseases including asthma.		 None ADULT and CHILD more than 12 years : 1 puff twice daily
37 Terbutaline Sulphate 0.5mg/ml Injection R03CC03-183-P30-01-XXX B Bronchial asthma, chronic bronchitis, emphysema and other lung diseases where broncoconstriction is a complicating factor None SC, IM or slow IV : 250-500 mcg up to 4 times daily. CHILD 2 - 15 years 10mcg/kg to a maximum of 300 mcg. Continuous IV infusion, as a solution containing 3 - 5 mcg/ml, 1.5 - 5 mcg/minute for 8 - 10 hours; reduce dose for children
38 Terbutaline Sulphate 10mg/ml Nebulizer Solution R03AC03-183-A30-01-XXX B Asthma and other conditions associated with reversible airways obstruction None ADULT : 5 - 10 mg 2 -4 times daily, additional doses may be necessary in severe acute asthma. CHILD up to 3 years : 2 mg, 3 - 6 years : 3 mg, 6 - 8 years : 4 mg, over 8 years : 5 mg 2 - 4 times daily
39 Theophylline 125mg Tablet R03DA04-000-T10-01-XXX B Reversible airways obstruction, acute severe asthma None ADULT: 125 mg 3 - 4 times daily after food, increased to 250 mg if required.
CHILD: 1 - 15 years : 5 mg/kg/dose (up to 600 mg/ day) every 3 - 4 times daily
40 Theophylline 250mg Long Acting Tablet R03DA04-000-T50-01-XXX B Reversible airways obstruction and acute severe asthma None ADULT: 250 mg 2 times daily. CHILD under 12 years : Up to 10 mg/kg body weight 2 times daily
41 Theophylline 80mg/15ml Syrup R03DA04-000-L90-01-XXX B Reversible airways obstruction and acute severe asthma None ADULT : 125 mg 3 - 4 times daily after food, increased to 250 mg if required. CHILD 1 - 15 years : 5 mg/kg/dose (up to 600 mg/day) every 3 - 4 times per day
42 Tiotropium 2.5mcg/puff solution for inhalation R03BB04-320-A30-01-XXX A/KK i) Maintenance bronchodilator treatment to relieve symptoms of patients with chronic obstructive pulmonary disease (COPD).
ii) As add-on maintenance bronchodilator treatment in adult patients (18 years and older) with asthma who are currently treated with the maintenance combination of inhaled corticosteroids (≥800µg budesonide/day or equivalent) and long-acting β2-agonist and who experienced one or more severe exacerbations in the previous year.		 For indication (i): The diagnosis of COPD should be confirmed by spirometry.
 5 mcg (2 puff) once daily, at the same time of the day

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