Formulari Ubat KKM (FUKKM)

# Generic Name MDC Category Indications Pres. Restrictions Dosage
481 Diazepam 5mg Rectal Solution N05BA01-000-G20-01-XXX B i) Status epilepticus
ii) Skeletal muscle spasm		 None Status epilepticus - ADULT: 0.5 mg/kg repeated after 12 hours if necessary. CHILD (febrile convulsions, prolonged or recurrent): 0.5 mg/kg (maximum 10 mg), repeated if necessary. Not recommended for children below 2 years
482 Diazepam 5mg Tablet N05BA01-000-T10-02-XXX B i) Muscle spasm of varied aetiology, including tetanus
ii) Anxiety disorders		 None i) ADULT: 2-10 mg 3-4 times daily.
CHILD 6 months and older: 0.12 - 0.8 mg/kg daily in divided doses, every 6-8 hours

ii) ADULT : 2 mg 3 times daily, increased in severe anxiety to 15 - 30 mg daily in divided doses.
ELDERLY (or debilitated) half adult dose.
CHILD (night terrors), 1 - 5 mg at bedtime
483 Diazepam 5mg/ml Injection N05BA01-000-P30-01-XXX B i) Status epilepticus
ii) Skeletal muscle spasm
iii) Anxiety disorders		 None i) ADULT: initial dose 10-20mg IV, in the following hours 20mg IM or by intravenous drip infusion as necessary.
CHILD 2 to 5 years of age: slow IV 0.2 - 0.5mg every two to five minutes up to a maximum of 5mg. If necessary, dose can be repeated in two to four hours.
CHILD 5 years and older: slow IV 1mg every two to five minutes up to a maximum of 10mg. If necessary, dose can be repeated in two to four hours.

ii) ADULT: 10mg once or twice IV.
CHILD 2 to 5 years of age: IM or IV, 1 to 2mg the dosage being repeated every three to four hours as needed.
CHILD 5 years and older: IM or IV, 5 to 10mg, the dosage being repeated every three to four hours as needed.

iii) ADULT: 10-20mg three times daily IM or IV until acute symptoms subside.
484 Diclofenac 1% Gel M02AA15-520-G30-01-XXX A i) Post-traumatic inflammation of the tendons,ligaments & joints.
ii) Localised forms of soft tissue rheumatism and degenerative rheumatism		 None Apply 3 - 4 times daily and gently rubbed in
485 Diclofenac 12.5mg Suppository M01AB05-520-S20-01-XXX A Pain and inflammation in rheumatic disease and juvenile arthritis None ADULT: 100 mg usually at night, max total daily dose 150 mg.
CHILD ABOVE 1 YEAR AND ADOLESCENT: 0.5-2mg/kg daily divided to 2-3 doses. Maximum dose for juvenile RA is 3mg/kg/day in divided doses
486 Diclofenac 25mg Suppository M01AB05-520-S20-02-XXX A Pain and inflammation in rheumatic disease and juvenile arthritis None ADULT: 100 mg usually at night, max total daily dose 150 mg.
CHILD ABOVE 1 YEAR AND ADOLESCENT: 0.5-2mg/kg daily divided to 2-3 doses. Maximum dose for juvenile RA is 3mg/kg/day in divided doses
487 Diclofenac 50mg Tablet M01AB05-520-T10-01-XXX B Pain and inflammation in rheumatic disease and of non-rheumatic origin None ADULTS: Initial dose of 150 mg daily. Mild or long term: 75 - 150 mg daily in 2 to 3 divided doses after food. Maximum: 200mg/day.
CHILD more than 6 months : 1 - 3 mg/kg body weight daily in divided doses. Maximum: 3mg/kg/day (150mg/day).
488 Diclofenac Sodium 50 mg Suppository M01AB05-520-S20-03-XXX A Pain and inflammation in rheumatic disease and juvenile arthritis None ADULT: 100 mg usually at night, max total daily dose 150 mg.
CHILD ABOVE 1 YEAR AND ADOLESCENT: 0.5-2mg/kg daily divided to 2-3 doses. Maximum dose for juvenile RA is 3mg/kg/day in divided doses
489 Diclofenac Sodium 75 mg/3ml Injection M01AB05-520-P30-01-XXX A/KK Pain and inflammation in rheumatic disease and of non-rheumatic origin None IM 75 mg once daily (2 times daily in severe cases) for not more than 2 days. Max 150mg/day.
Not suitable for children.
490 Didanosine 100 mg Tablet (ddI) J05AF02000T1002XX A* HIV infection, in combination with other antiretrovirals ADULT less than 60 kg: 125 mg twice daily or 250 mg once daily; more than 60 kg: 400 mg once daily or 200 mg twice daily. CHILD: 2 weeks to less than 3 months: 50mg/m2 twice daily; 3-8 months: 100mg/m2 twice daily
491 Didanosine 2 g Oral Solution (ddI) J05AF02000F2101XX A* HIV infection, in combination with other antiretrovirals ADULT less than 60 kg: 125 mg twice daily or 250 mg once daily; more than 60 kg: 400 mg once daily or 200 mg twice daily. CHILD: 2 weeks to less than 3 months: 50mg/m2 twice daily; 3-8 months: 100mg/m2 twice daily
492 Didanosine 25 mg Tablet (ddI) J05AF02000T1001XX A* HIV infection, in combination with other antiretrovirals ADULT less than 60 kg: 125 mg twice daily or 250 mg once daily; more than 60 kg: 400 mg once daily or 200 mg twice daily. CHILD: 2 weeks to less than 3 months: 50mg/m2 twice daily; 3-8 months: 100mg/m2 twice daily
493 Didanosine 250 mg Enteric Coated Capsule J05AF02000C1001XX A* HIV infection, in combination with other antiretrovirals ADULT less than 60 kg: 250 mg once daily; 60 kg or greater: 400 mg once daily. Dose may varies if taken in combination with tenofovir
494 Didanosine 400 mg Enteric Coated Capsule J05AF02000C1002XX A* HIV infection, in combination with other antiretrovirals ADULT less than 60 kg: 250 mg once daily; 60 kg or greater: 400 mg once daily. Dose may varies if taken in combination with tenofovir
495 Dienogest 2mg tablet G03DB08-000-T10-01-XXX A/KK Treatment of endometriosis None One tablet daily. Treatment can be started on any day of menstrual cycle. Tablets must be taken continously without regard to vaginal bleeding.
496 Diethylcarbamazine Citrate 50mg Tablet P02CB02-136-T10-01-XXX B i) Bancrofti filariasis, onchocerciasis, loasis, creeping eruption
ii) Ascariasis
iii) Tropical eosinophilia		 None i) 1 mg/kg on the first day and increased gradually over 3 days to 6 mg/kg daily in divided doses. This dosage is maintained for 21 days.
ii) 13 mg/kg once daily for 7 days. CHILD : 6 - 10 mg/kg 3 times daily for 7 days
iii) 6 mg/kg/day in 3 divided doses for 21 days
497 Digoxin 0.25mg Tablet C01AA05-000-T10-01-XX B Heart failure , with atrial fibrillation, supraventricular arrhythmias (particularly, atrial fibrillation) None Rapid digitalisation: 0.75 -1.5 mg in divided doses over 24 hours; less urgent digitalisation, 250 mcg-500 mcg daily (higher dose may be divided). Maintenance : 62.5mcg -500 mcg daily (higher dose may be divided) according to renal function and , in atrial fibrillation, on heart rate response; usual range, 125-250 mcg daily (lower dose may be appropriate in elderly)
498 Digoxin 250mcg/ml Injection C01AA05-000-P30-01-XX A Heart failure with atrial fibrillation, supraventricular arrhythmias (particularly atrial fibrillation) None Rapid digitilisation: ADULT & CHILD over 10 years, initially 0.75 - 1.5 mg, followed by 250 mcg 6 hourly until digitilisation is complete
499 Digoxin 50mcg/ml Elixir C01AA05-000-L10-01-XX B Heart failure, supraventricular arrhythmias (particularly atrial fibrillation) None Rapid digitalization, give in divided doses; PREMATURE: 20-30 mcg/kg; FULLTERM: 25-35 mcg/kg; CHILD 1-2 years : 35 to 60 mcg/kg; CHILD 2-5 years: 30-40 mcg/kg; CHILD 5-10 years: 20- 35 mcg/kg; CHILD over 10 years: 10-15 mcg/kg. For daily maintenance doses or for gradual digitalization, give 20% to 30% of oral digitalizing dose for premature infants or 25% to 35% of oral digitalizing dose for all other pediatric patients
500 Digoxin 62.5mcg Tablet C01AA05-000-T10-02-XX B Heart failure, with atrial fibrillation, supraventricular arrhythmias (particularly, atrial fibrillation) None Rapid digitalisation: 1-1.5 mg in divided doses over 24 hours; less urgent digitalisation, 250 mcg-500 mcg daily (higher dose may be divided). Maintenance: 62.5 - 500 mcg daily (higher dose may be divided) according to renal function, and in atrial fibrillation, on heart-response; usual range :125 - 250 mcg daily (lower doses may be appropriate in the elderly)
501 Dihydrocodeine Tartrate 30 mg Tablet N02AA08-123-T10-01-XXX B For the control of moderate to severe chronic pain None ADULT: 30 - 60 mg every 4 - 6 hours.
CHILD, over 4 yrs: 0.5 - 1 mg/kg body weight every 4-6 hours
502 Diltiazem HCl 100mg sustained release capsule C08DB01-110-C20-05-001 A/KK Treatment of angina pectoris in the following cases:
i. Inadequate response or intolerance to beta-blockers and Isosorbide Dinitrate
ii. Contraindication to beta-blockers
iii. Coronary artery spasm		 None Usually, for adults, 100 mg to 200 mg to be administered orally once daily. If the effect is insufficient, the dosage may be increased to 200 mg once daily.
503 Diltiazem HCl 30 mg Tablet C08DB01-110-T10-01-XX B i) Treatment of angina
ii) Hypertension		 None Initially 30mg tds, may increase to 60mg tds (elderly initially twice daily; increased if necessary to 360 mg daily.
504 Dimenhydrinate Injection 10ml/vial (50mg/ml) N07CA00000P2001XX B Prevention and relief of motion sickness, treatment of vertigo, nausea or vomiting associated with electroshock therapy, anaesthesia and surgery; labyrinthine disturbances and radiation sickness. Usual Adult & Adolescent Dose: Antiemetic; or Antivertigo agent ? Intramuscular, 50 mg repeated every four hours as needed. Intravenous, 50 mg in 10 mL of 0.9% sodium chloride injection, administered slowly over a period of at least two minutes, repeated every four hours as needed. Usual Pediatric Dose: Antiemetic; or Antivertigo agent ? Intramuscular, 1.25 mg per kg of body weight or 37.5 mg per square meter of body surface, every six hours as needed, not to exceed 300 mg per day. Intravenous, 1.25 mg per kg of body weight or 37.5 mg per square meter of body surface, in 10 ml of 0.9% sodium chloride injection, administered slowly over a period of at least two minutes, every six hours as needed, not to exceed 300 mg per day.
505 Dimenhydrinate Syrup 15mg/5ml N07CA00000L9003XX B For prevention and treatment of motion sickness. Also used as anti-emetic agent in irradiation sickness, postoperative vomiting, drug induced nausea and vomiting, and for symptomatic treatment of nausea and vertigo due to Meniere`s disease and other labyrinthine disturbances. ADULT: 50-100 mg every 4 hours as needed. For motion sickness, take medicine at least 30 minutes, and preferably 1-2 hours before travelling. Usual adult prescribing limit: Up to 400 mg daily. CHILD: Children 6-12 years: 25-50 mg every 6-8 hours as needed (maximum of 150 mg daily).
506 Dimercaprol 50 mg/ml Injection V03AB09-000-P30-01-XXX B Poisoning by antimony, arsenic, bismuth, gold, mercury, possibly thallium; adjunct (with calcium disodium edetate) in lead poisoning None By IM: 2.5 - 3 mg/kg every 4 hours for 2 days, 2 - 4 times on the third day, then 1 - 2 times daily for 10 days or until recovery. For ophthalmic use : instillation of 50 mg/ml oily solution in conjunctival sac, within 5 minutes of contamination
507 Dinoprostone (Prostagladin E2) 3mg Vaginal Tablet G02AD02-000-S10-01-XXX A Induction of labour None 3 mg vaginal tablet to be inserted high into the posterior formix. A second 3 mg tablet may be inserted after 6-8 hours if labour is not established. Max 6 mg
508 Diosmin 450mg and Hesperidin 50mg Tablet C05CA533-931-T10-01-XX B i) Haemorrhoids ii) Chronic venous insufficiency None i) Acute attack: 6 tablets daily for the first 4 days, then 4 tablets daily in 2 divided doses for 3 days and 2 tablets thereafter. Chronic: 2 tablets daily ii) 2 tab daily with meals
509 Diphenhydramine Hydrochloride 14mg/5ml Expectorant R06AA52-110-L21-01-XXX C Cough None ADULT : 5 - 10 ml 2 - 3 times daily.
510 Diphenhydramine Hydrochloride 7 mg/5 ml Expectorant R06AA52-110-L90-03-XXX C Cough None CHILD 6-12 years: 2.5 to 5 ml 2-3 times daily
CHILD 2-5 years: 2.5 ml 2-3 times daily
NOT to be used in children less than 2 years in age

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