Formulari Ubat KKM (FUKKM)

# Generic Name MDC Category Indications Pres. Restrictions Dosage
1561 Tetracycline HCl 250 mg Capsule J01AA07110C1001XX B Infections caused by susceptible pathogens "Adult: 250-500 mg 6 hrly. Max: 4 g/day. Child: ≥12 yr Max: 2 g daily"
1562 Tetracycline HCl 250 mg Tablet J01AA07110T1001XX B Infections caused by susceptible pathogens "Adult: 250-500 mg 6 hrly. Max: 4 g/day. Child: ≥12 yr Max: 2 g daily"
1563 Thalidomide 50 mg Capsule L04AX02000C1001XX A* Treatment of multiple myeloma. 50 mg to 200 mg daily
1564 Thallous Chloride (Thallium-201) Injection V09GX01100P3001XX A* Used in myocardial perfusion scintigraphy, acute myocardial infarction and post-surgical assessment of coronary artery bypass graft patency, muscle perfusion scintigraphy, visualisation of brain and thyroid tumours and metastases As IV infusion
1565 Theophylline 125mg Tablet R03DA04-000-T10-01-XXX B Reversible airways obstruction, acute severe asthma None ADULT: 125 mg 3 - 4 times daily after food, increased to 250 mg if required.
CHILD: 1 - 15 years : 5 mg/kg/dose (up to 600 mg/ day) every 3 - 4 times daily
1566 Theophylline 250mg Long Acting Tablet R03DA04-000-T50-01-XXX B Reversible airways obstruction and acute severe asthma None ADULT: 250 mg 2 times daily. CHILD under 12 years : Up to 10 mg/kg body weight 2 times daily
1567 Theophylline 80mg/15ml Syrup R03DA04-000-L90-01-XXX B Reversible airways obstruction and acute severe asthma None ADULT : 125 mg 3 - 4 times daily after food, increased to 250 mg if required. CHILD 1 - 15 years : 5 mg/kg/dose (up to 600 mg/day) every 3 - 4 times per day
1568 Thiamine HCl 100mg/ml Injection A11DA01110P3001XX B i) For the prevention or treatment of Vitamin B1 deficiency syndromes including beri-beri and peripheral neuritis associated with pellagra ii) Wernicke-Korsakoff Syndrome i) Mild to chronic deficiency: 10-25 mg daily. Severe deficiency: 200- 300 mg daily ii) 500 mg every 8 hours for 2 days, followed by 100 mg 2 times daily until patient can take oral dose
1569 Thiamine Mononitrate 10mg Tablet A11DA01-221-T10-02-XXX C Prevention and treatment of thiamine deficiency state - Mild chronic deficiency: 5mg to 30mg daily
Severe deficiency: up to 300mg daily
1570 Thiamine Mononitrate 3mg Tablet A11DA01-221-T10-01-XXX C Prevention and treatment of thiamine deficiency state - Mild chronic deficiency: 5mg to 30mg daily
Severe deficiency: up to 300mg daily
1571 Thioguanine 40 mg Tablet L01BB03000T1001XX A For acute leukaemia and chronic granulocytic leukaemia Refer to specific protocols. Usually 100 mg/m2 for 5 - 7 days (acute myeloid leukaemia) or up to 2 weeks (chronic myeloid leukaemia for accelerated/ advanced disease). CHILD: 40 - 60 g/m2 daily according to protocol
1572 Thiopental Sodium 500mg Injection N05CA19-520-P30-01-XXX B i) General anaesthesia, induction
ii) Anticonvulsant for cases resistant to conventional anticonvulsants in the ICU		 None i) ADULT : For induction 200 - 400 mg. For repeat injection 3 - 5 mg/kg over 10 - 15 seconds until desired depth of anaesthesia is obtained. Not FDA approved for use in pediatric patients ii) 75 - 125 mg IV single dose; for local-anaesthetic induced convulsion: 125 - 250 mg IV over 10 minutes
1573 Thymol Compound Gargle A01AD11985M2001XX C For sore throat and minor mouth inflammation To be gargled 3-4 times daily
1574 Thyrotropin alfa 0.9mg/ml Injection H01AB01000P3002XX A* Thyrogen (thyrotropin alfa) is indicated for use as an adjunctive treatment for radioiodine ablation of thyroid tissue remnants in patients who have undergone a near-total or total thyroidectomy for well-differentiated thyroid cancer and who do not have evidence of distant metastatic thyroid cancer. A two-injection regimen is recommended for thyrotropin administration.
The two-injection regimen is thyrotropin 0.9 mg intramuscularly (IM), followed by a second 0.9 mg IM injection 24 hours later.
After reconstitution with 1.2 mL Sterile Water for Injection, 1.0 mL solution (0.9 mg thyrotropin alfa) is administered by intramuscular injection to the buttock.

For radioiodine imaging or treatment, radioiodine administration should be given 24 hours following the final Thyrogen injection. Diagnostic scanning should be performed 48 hours after radioiodine administration, whereas post-therapy scanning may be delayed additional days to allow background activity to decline.
1575 Tibolone 2.5 mg Tablet G03CX01-000-T10-01-XXX A* i. Treatment of complaints resulting from the natural or surgical menopause & in cases at high risk for breast carcinomas where general hormone replacement therapy is contraindicated

ii. Prevention of osteoporosis in postmenopausal women at high risk of future fractures who are intolerant of, or contraindicated for, other medicinal products approved for the prevention of osteoporosis.		 - 2.5mg daily
1576 Ticagrelor 90 mg Tablet B01AC24-000-T10-01-XXX A* Co-administration with aspirin, for the prevention of atherothrombotic events:

a) Second line treatment for patients readmitted to hospital with recurrent atherothrombotic event failing treatment with clopidogrel.
b) STEMI patients going for invasive PCI
c) NSTEMI/UA patients with intermediate to high risk TIMI score
d) Other complicated ACS cases treated either medically or invasively via PCI or CABG (risk of Stent thrombosis, 3VD etc.)		 Initially, 180mg as single dose followed by 90mg bd with maintenance dose of ASA 75-150 mg daily.
1577 Ticlopidine HCl 250 mg Tablet B01AC05110T1001XX A/KK i) Prevention of thrombotic stroke for patients who are sensitive /intolerant to Acetysalicylic Acid ii) Maintenance of coronary bypass surgery or angioplasty iii) Maintenance of patency of access in patients on chronic haemodialysis 250 mg twice daily taken with food
1578 Timolol 0.5% Eye Drops S01ED01-253-D20-02-XX A Elevated intraocular pressure, chronic open angle glaucoma None One drop in the affected eye(s) twice daily or as directed by physician
1579 Timolol 0.5% Ophthalmic Gel Forming Solution S01ED01-253-D20-02-XXX A Elevated intraocular pressure, chronic open angle glaucoma None One drop in the affected eye(s) once a day
1580 Tinidazole 500 mg Tablet P01AB02000T1001XX B i) Amoebiasis ii) Urogenital trichomoniasis and giardiasis i) ADULT : 2 g as a single dose for 2 - 3 days. CHILD 3 years and older : 50 mg/kg daily for 3 days ii) ADULT : 2 g as a single dose (repeated once if necessary). Sexual partners should be treated concomitantly with the same dose. CHILD 6 years and older : single dose of 1 gram
1581 Tiotropium 2.5mcg and Olodaterol 2.5mcg per actuation, inhalation R03AL06-989-A10-01-XXX A/KK As a maintenance bronchodilator treatment to relieve symptoms in adult patients with chronic obstructive pulmonary disease (COPD). Patients without inhaler coordination problem (Only applies to Primary Care settings) 2 puffs once daily, at the same time of the day.
1582 Tiotropium 2.5mcg/puff solution for inhalation R03BB04-320-A30-01-XXX A/KK i) Maintenance bronchodilator treatment to relieve symptoms of patients with chronic obstructive pulmonary disease (COPD).
ii) As add-on maintenance bronchodilator treatment in adult patients (18 years and older) with asthma who are currently treated with the maintenance combination of inhaled corticosteroids (≥800µg budesonide/day or equivalent) and long-acting β2-agonist and who experienced one or more severe exacerbations in the previous year.		 For indication (i): The diagnosis of COPD should be confirmed by spirometry.
 5 mcg (2 puff) once daily, at the same time of the day
1583 Tirofiban HCl 0.25 mg/ml Injection B01AC17110P9901XX A* Unstable angina or non-ST segment elevation myocardial infarction with the following: elevated cardiac markers, refractory chest pain, ST-segment changes and thrombolysis in myocardial infarction (TIMI) risk score 4 By IV infusion, 0.4 mcg/kg/min for 30 minutes, then 0.1 mcg/kg/min for at least 48 hours, maximum 108 hours
1584 Tocilizumab 162mg/0.9ml solution for injection in prefilled syringe (for subcutaneous injection) L04AC07000P3003XX A* Indicated for the treatment of moderate to severe active rheumatoid arthritis (RA) in adult patients:
i) with inadequate respond or intolerance to conventional disease- modifying antirheumatic drugs (DMARDS)
ii) who has failed antitumour necrosis factors (antiTNFs)
iii) where TNF is contraindicated (patients with history of pulmonary tuberculosis [PTB])
It also can be used as monotherapy or with combination with methotrexate (MTX) and/ or other DMARDS.		 Adult patients: 162mg given once every week as a subcutaneous injection.
1585 Tocilizumab 20 mg/ml Injection L04AC07-000-P30-01-001 A* Indicated for the treatment of moderate to severe active rheumatoid arthritis (RA) in adult patients:
i) with inadequate respond or intolerance to conventional disease- modifying antirheumatic drugs (DMARDS)
ii) who has failed antitumour necrosis factors (antiTNFs)
iii) where TNF is contraindicated (patients with history of pulmonary tuberculosis [PTB]) It also can be used as monotherapy or with combination with methotrexate (MTX) and/ or other DMARDS.		 Recommended dose for rheumatoid arthritis of tocilizumab for adult patients is 8mg/kg given once every 4 weeks as a single-drip IV infusion over 1 hour. It should be diluted to 100 ml by a healthcare professional with sterile 0.9% w/v sodium chloride solution over 1 hour. For patients whose body weight is more than 100kg, doses exceeding 800mg per infusion are not recommended
1586 Tofacitinib citrate 5mg film coated tablet L04AA29136T3201XX A* Indicated for the treatment of adult patients with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerance to methotrexate. It may be used as monotherapy or in combination with methotrexate or other non-biologic disease-modifying anti-rheumatic drugs (DMARDs). One tablet twice daily
1587 Tolterodine Tartrate ER 4 mg Capsule G04BD07-123-C20-02-XXX A* Treatment of overactive bladder with symptoms of urinary, frequency or urge incontinence - 4 mg once daily. May decrease to 2 mg once daily depending on response and tolerability
1588 Topiramate 100 mg Tablet N03AX11-000-T10-03-XXX A* As adjunctive therapy for adults and children (2 years and above) with:
i) partial onset seizures and generalized tonic-clonic seizures
ii) seizures associated with Lennox Gastaut syndrome.		 ADULT: Usual daily dose: 200-400 mg/day.
CHILD: Daily doses up to 30mg/kg/day

Dosing is according to product insert.
1589 Topiramate 25 mg Capsule Sprinkle N03AX11000C1002XX A* Add-on therapy for intractable partial epilepsy ADULT: Initially 25-50mg nightly for 1 week. Subsequently at wkly or bi-wkly intervals, increase dose by 25-50 to 100mg/day in 2 divided doses. CHILD aged 2 and above: Approx 5-9 mg/kg/day in 2 divided doses. Titrate at 25mg (or less, based on a range of 1-3mg/kg/day) nightly for the 1st week. Subsequently at 1 or 2 wkly intervals, with increments of 1-3 mg/kg/day in 2 divided dose.
1590 Topiramate 25 mg Tablet N03AX11-000-T10-01-XXX A* As adjunctive therapy for adults and children (2 years and above) with:
i) partial onset seizures and generalized tonic-clonic seizures
ii) seizures associated with Lennox Gastaut syndrome.		 ADULT: Usual daily dose: 200-400 mg/day.
CHILD: Daily doses up to 30mg/kg/day

Dosing is according to product insert.

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