Formulari Ubat KKM (FUKKM)

# Generic Name MDC Category Indications Pres. Restrictions Dosage
331 Chlorpheniramine Maleate 10mg/ml Injection R06AB04-253-P30-01-XX B Allergic conditions None 10 - 20 mg IM or SC, repeated if required. Not to exceed 40 mg in 24 hours. 10 - 20 mg over 1 minute by slow IV
332 Chlorpheniramine Maleate 2mg/5ml Syrup R06AB04-253-L90-01-XXX C Symptomatic treatment of allergic conditions responsive to antihistamine None CHILD 2 - 5 years : 1 mg every 4 - 6 hours (maximum 6 mg daily) 6 - 12 years : 2 mg every 4 - 6 hours (maximum 12 mg daily)
333 Chlorpheniramine Maleate 4mg Tablet R06AB04-253-T10-01-XXX C Symptomatic treatment of allergic conditions responsive to antihistamines None ADULT : 4 mg every 4 - 6 hours. Maximum 24 mg daily.
CHILD 2 - 5 years : 1 mg every 4 - 6 hours (maximum 6 mg daily) 6 - 12 years : 2 mg every 4 - 6 hours (maximum 12 mg daily)
334 Chlorpromazine HCl 100mg Tablet N05AA01-110-T10-02-XXX B i) Psychotic conditions
ii) Anti-emetic		 None ADULT:
Initial: 25-50mg two- three times daily
Maintenance: 25-100mg two- three times daily

CHILD: Not recommended

Dosing is according to product insert / protocol.
335 Chlorpromazine HCl 25mg Tablet N05AA01-110-T10-01-XXX B i) Psychotic conditions
ii) Anti-emetic		 None ADULT:
Initial: 25-50mg two- three times daily
Maintenance: 25-100mg two- three times daily

CHILD: Not recommended

Dosing is according to product insert / protocol.
336 Chlortetracycline 1-3 % Cream D06AA02000G1001XX B Bacterial skin infections Apply directly to affected area twice daily as required for 1 - 2 weeks
337 Cholecalciferol 1,000 iu Tablet None A/KK 1. Treatment of vitamin D deficiency
2. Adjuvant treatment for osteoporosis		 None 1. 1000 - 4000 IU/day
2. 1000 IU/day
338 Cholera Vaccine Oral Suspension J07AE01000P3001XX B Immunisation against cholera. Two doses of vaccines should be given at an interval of two weeks.
339 Cholestyramine Resin 4G C10AC01-000-M40-01-XX A i) Hypercholesterolemia ii) Familial hypercholesterolemia - heterozygous iii) Generalized atherosclerosis iv) Diarrhoea due to bile acid malabsorption v) Pruritus of skin associated with partial biliary obstruction None Hypercholesterolemia: Adjunct: initial, 4 g orally 1-2 times daily, maintenance, 8 to 16 g in divided doses, max 24 g daily CHILD: 50 - 150 mg/ kg 6 - 8 hourly oral
340 Choline Salicylate 8.7%, Cetylkonium Chloride 0.01% Dental Gel N02BA03-900-G30-01-XXX B For relief of the pain and discomfort in mouth ulcers and sores, infant teething and denture irritation None Apply to area 4 times daily
341 Choriogonadotropin Alfa 250mcg/0.5 ml Injection in Prefilled Syringe G03GA01-000-P50-01-XXX A* Indicated in the treatment of:
i. Adult women undergoing superovulation prior to assisted reproductive technologies (ART), to trigger final follicular maturation and luteinisation after stimulation of follicular growth
ii. Anovulatory or oligo-ovulatory women, to trigger ovulation and luteinisation after stimulation of follicular growth		 None 250 mcg 24-48 hours after optimal stimulation of follicular growth is achieved

Dosing is individualised and according to product insert/protocol
342 Chorionic Gonadotrophin Human (HCG) 5000IU Injection G03GA01-000-P40-01-XXX A* In the female:
i. Ovulation induction in subfertility due to anovulation or impaired follicle-ripening.
ii. Preparation of follicles for puncture in controlled ovarian hyperstimulation (for assisted reproductive technologies).
iii. Luteal phase support.


In the male:
iv)Hypogonadotropic hypogonadism(also cases of idiopathic dysspermias have shown a positive response to gonadotropins),
v) Delayed puberty associated with insufficient gonadotropic pituitary function
vi) cryptorchidism not due to an anatomic obstruction.		 None i & ii: 5,000-10,000 IU stat once optimal stimulation of follicular growth is achieved.
iii: Up to three repeat injections of 1000 to 3000 IU may be given within 9 days following ovulation or embryo transfer (E.g.: on day 3, 6 and 9 after ovulation induction)

iv) 1000 - 2000 IU, two to three times per week
v)1500IU two to three times weekly for at least six months
vi) < 2 years of age: 250 IU twice weekly for six weeks
< 6 years of age: 500 - 1000 IU twice weekly for six weeks > 6 years of age: 1500 IU twice weekly for six weeks.

Dosing is individualised and according to product insert / protocol.
343 Ciclesonide 160mcg/dose Inhaler R03BA08-000-A21-01-XXX A* Prophylactic treatment of asthma in adults, adolescents and children over 6 years. The use of this drug in MOH is restricted to pediatric patient only. For adults and adolescents over 12 years of age with mild to moderate asthma is 160 to 640mcg per day: severe asthma dose may be increased to 1280mcg per day.
344 Ciclosporin 100 mg Capsule L04AD01000C1002XX A* i) Patients in whom donor specific transplantation cannot be carried out and in young children to minimise side-effects of steroids
ii) Follow-up cases of bone marrow transplant
iii) Patients with severe rheumatoid arthritis not responding to other second line drugs
iv) Patients with idiopathic nephrotic syndrome who are steroid toxic or poor response to cyclophosphamide
v) Severe aplastic anemia, pure red cell aplasia
vi) Cases of recalcitrant psoriasis and atopic eczema
vii) Treatment of chronic ocular inflammatory disorders/uveitis		 i & ii)
Initially 12.5 - 15 mg/kg/day, beginning on the day before transplant. Maintenance approx 12.5 mg/kg/day for 3 - 6 months before being tapered off to zero by 1 year of transplantation

iii) 3 mg/kg/day in 2 divided doses for first 6 weeks. May increased gradually to maximum 5 mg/kg. Treatment withdrawn if no response after 3 months
iv) ADULT: 5 mg/kg/day in 2 divided doses. CHILD: 6 mg/kg/day in 2 divided doses. Patients with permitted levels of kidney failure, the starting dose must not more than 2.5 mg/kg/day
v) 12 mg/kg/day
vi) 2.5 mg/kg/day in 2 divided doses increasing if there is no improvement after 4 weeks by 0.5 -1 mg/kg/month up to maximum 5 mg/kg/day
vii) 5 mg/kg/day in 2 divided doses, may increase to 7 mg/kg/day in resistant cases. Maintenance: Less than 5 mg/kg/day especially during remission
345 Ciclosporin 100 mg/ml Oral Solution L04AD01000L5002XX A* i) Patients in whom donor specific transplantation cannot be carried out and in young children to minimise side-effects of steroids
ii) Follow-up cases of bone marrow transplant
iii) Patients with severe Rheumatoid arthritis not responding to other second line drugs
iv) Patients with idiopathic nephrotic syndrome who are steroid toxic or poor response to cyclophosphamide
v) Severe aplastic anaemia, pure red cell aplasia
vi) Cases of recalcitrant psoriasis and atopic eczema		 i & ii)
Initially 12.5 - 15 mg/kg/day, beginning on the day before transplant. Maintenance approx 12.5 mg/kg/day for 3 - 6 months before being tapered off to zero by 1 year of transplantation

iii) 3 mg/kg/day in 2 divided doses for first 6 weeks. May increased gradually to maximum 5 mg/kg. Treatment withdrawn if no response after 3 months
iv) ADULT: 5 mg/kg/day in 2 divided doses. CHILD: 6 mg/kg/day in 2 divided doses. Patients with permitted levels of kidney failure, the starting dose must not more than 2.5 mg/kg/day
v) 12 mg/kg/day
vi) 2.5 mg/kg/day in 2 divided doses increasing if there is no improvement after 4 weeks by 0.5 -1 mg/kg/month up to maximum 5 mg/kg/day
346 Ciclosporin 25 mg Capsule L04AD01000C1001XX A* i) Patients in whom donor specific transplantation cannot be carried out and in young children to minimise side-effects of steroids
ii) Follow-up cases of bone marrow transplant
iii) Patients with severe rheumatoid arthritis not responding to other second line drugs
iv) Patients with idiopathic nephrotic syndrome who are steroid toxic or poor response to cyclophosphamide
v) Severe aplastic anemia, pure red cell aplasia
vi) Cases of recalcitrant psoriasis and atopic eczema
vii) Treatment of chronic ocular inflammatory disorders/uveitis		 i & ii)
Initially 12.5 - 15 mg/kg/day, beginning on the day before transplant. Maintenance approx 12.5 mg/kg/day for 3 - 6 months before being tapered off to zero by 1 year of transplantation

iii) 3 mg/kg/day in 2 divided doses for first 6 weeks. May increased gradually to maximum 5 mg/kg. Treatment withdrawn if no response after 3 months
iv) ADULT: 5 mg/kg/day in 2 divided doses. CHILD: 6 mg/kg/day in 2 divided doses. Patients with permitted levels of kidney failure, the starting dose must not more than 2.5 mg/kg/day
v) 12 mg/kg/day
vi) 2.5 mg/kg/day in 2 divided doses increasing if there is no improvement after 4 weeks by 0.5 -1 mg/kg/month up to maximum 5 mg/kg/day
vii) 5 mg/kg/day in 2 divided doses, may increase to 7 mg/kg/day in resistant cases. Maintenance: Less than 5 mg/kg/day especially during remission
347 Ciclosporin 50 mg/ml Injection L04AD01000P3001XX A* i) Post bone marrow transplant
ii) Solid organ transplant		 i) 3 - 5 mg/kg/day until tolerate orally
ii) 2 - 3 mg/kg/day for recipients who are unable to take orally
348 Ciclosporin Ophthalmic Emulsion 0.05% S01XA18-000-D20-01-XXX A* To increase tear production in patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sicca. Increased tear production was not seen in patients currently taking anti inflammatory drugs or using punctal plugs. None 1 drop twice a day in each eye approximately 12 hours apart.
349 Cilostazol 100mg Tablet B01AC00-000-T10-02-XXX A* Improvement of the maximal and pain-free walking distances in patients with intermittent claudication, who do not have rest pain and who do not have evidence of peripheral tissue necrosis. None 100 mg twice daily
350 Cimicifuga Racemosa Rhizome Extract Tablet HG03WA5-001-T10-01-XXX A Traditionally used for the relief of hot flushes, sweating, restlessness associated with menopause None 1 tablet twice a day (morning and evening)
351 Cinacalcet Hydrochloride 25mg tablet H05BX01-110-T10-01-XXX A* Secondary hyperparathyroidism in patients undergoing maintenance dialysis with hypercalcaemia. For treatment of refractory secondary hyperparathyroidism in patients with end-stage renal disease (including those with calciphylaxis) only in those:
i) who have 'very uncontrolled' plasma levels of intact parathyroid hormone (defined as greater than 85pmol/L [800 pg/mL] that are refractory to standard therapy, and an adjusted serum calcium level at upper limit of normal or high, despite appropriate adjustment of phosphate binders including non-calcium based phosphate binders.
ii) in whom surgical parathyroidectomy is contraindicated in that the risks of surgery are considered to outweigh the benefits, or if there is likely to be a significant delay for surgery.		 The starting dose for adults is 25mg once daily to be administered orally.
Depending on the serum parathyroid hormone (PTH) and calcium levels, the dose may be adjusted within a range of 25-75mg once daily. If no improvement in PTH, the dose may be increased up to 100 mg once daily. Dose can be increased by 25mg at a time at intervals of at least 3 weeks.
352 Cinnarizine 25mg Tablet N07CA02-000-T10-01-XXX B i) Vestibular disorders
ii) Motion sickness		 None i) ADULT and CHILD > 12years: 25mg three times a day
ii) 25mg 2 hours before travel and 12.5mg every 8 hours during journey
CHILD 5-12 years: Half the adult dose

Dosing is according to product insert.
353 Ciprofloxacin 100mg/50ml Injection J01MA02-125-P30-01-XXX A Treatment of infections due to susceptible bacterial strains None ADULT: the dosage range is 100-400mg twice daily Gonorrhoea: 100mg single dose Upper and Lower Urinary Tract Infection: 100mg bd Upper and Lower Respiratory Tract Infection: 200mg bd-400mg twice daily Cystic Fibrosis with psuedomonal Lower RTI: 400mg bd Others: 200-400mg bd inhalation Anthrax: 400mg bd
354 Ciprofloxacin 200mg/100ml Injection J01MA02-125-P30-02-XXX A Treatment of infections due to susceptible bacterial strains None Suggest to rephrase ADULT: the dosage range is 100-400mg twice daily Gonorrhoea: 100mg single dose Upper and Lower Urinary Tract Infection: 100mg bd Upper and Lower Respiratory Tract Infection: 200mg bd-400mg twice daily Cystic Fibrosis with psuedomonal Lower RTI: 400mg bd Others: 200-400mg bd inhalation Anthrax: 400mg bd
355 Ciprofloxacin 250mg Tablet J01MA02-110-T10-01-XXX A Treatment of infections due to susceptible bacterial strains None ADULT: 125-750 mg twice daily. Acute gonorrhoea: a single dose of 250 mg
356 Ciprofloxacin 500mg Tablet J01MA02-110-T10-02-XXX A Treatment of infections due to susceptible bacterial strains None ADULT: 125-750 mg twice daily. Acute gonorrhoea: a single dose of 250 mg
357 Ciprofloxacin HCl 0.3% Ophthalmic Solution S01AX13-110-D20-01-XXX A* Treatment of bacterial infections caused by susceptible strains in:
i) corneal ulcers
ii) bacterial conjunctivitis		 None i) 2 drops every 15 minutes for the first 6 hours, then 2 drops every 30 minutes for the rest of the first day. Second day : 2 drops every hour. Subsequent days (3rd - 14th day) : 2 drops every 4 hours. Treatment may be continued after 14 days if corneal re-epithelialization has not occured,
ii) 1 - 2 drops every 2 hours into the conjunctival sac while awake for 2 days and 1-2 drops every 4 hours while awake for the next 5 days
358 Cisatracurium Besylate 2mg/ml Injection M03AC11-197-P30-01-XXX A* As an adjunct to general anaesthesia to facilitate endotracheal intubation, to provide skeletal muscle relaxation during surgery and to facilitate mechanical ventilation. Restricted to patients with lung problem such as asthma. None Administered as bolus intravenous injection. May be administered as infusion in ICU patients at a rate of 3mcg/kg/min. Adult dose: a) Induction: 0.15mg/kg over 5-10 secs, b) Maintenance: 0.03 mg/kg. Children 2-12 years: a) Induction: 0.1 mg/kg over 5-10 secs, b) Maintenance: 0.02 mg/kg
359 Cisplatin 1 mg/mL Injection L01XA01000P3001XX A i) Solid tumours
ii) lymphomas		 Germ cell tumours: 20 mg/m2 daily for 5 days every 3 weeks for 3 - 4 courses. Ovarian tumours: 75 mg/m2 once every 3 weeks as part of combination therapy with paclitaxel or 50-60mg/m2 IV once every 3 weeks as a single agent. Baseline creatinine clearance, pretreatment hydration and forced diuresis are mandatory. CHILD: 100mg/m2 over 6 hours once every 3 weeks. Lymphomas: Refer to protocols CHILD: 100mg/m2 over 6 hours once every 3 weeks. Lymphomas: Refer to protocols
360 Clarithromycin 125mg/5ml Granules J01FA09-000-F10-01-XXX A* Treatment of complicated respiratory tract infections not responding to standard macrolides None CHILD: 8 - 12 years: 30 - 40 kg 10 mL, 4 - 8 years: 20 - 29 kg 7.5 mL, 2 - 4 years: 12 - 19 kg 5 mL, 1 - 2 years: 8 - 11 kg 2.5 mL, less than 8 kg: 7.5 mg/kg. To be given twice daily. Maximum dose: 1g/day

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