Formulari Ubat KKM (FUKKM)

# Generic Name MDC Category Indications Pres. Restrictions Dosage
361 Clarithromycin 250mg Tablet J01FA09-000-T10-01-XXX A* Only for:
i) treatment of complicated respiratory tract infection not responding to standard macrolides.
ii) eradication of Helicobacter pylori infection		 None i) 250 - 500 mg twice daily. Up to 6 - 14 days
ii) 500 mg twice daily with omeprazole & amoxicillin. Up to 2 weeks
362 Clarithromycin 500mg Injection J01FA09-000-P30-01-XXX A* Only for treatment of complicated respiratory tract infection not responding to standard macrolides None Susceptible infections Adult: 500 mg bid for 2-5 days. Dose to be infused over 60 minutes in a 0.2% solution; revert to oral therapy whenever possible. Child: 1 mth-12 yr: 7.5 mg/kg every 12 hr. Dose to be given via infusion into proximal vein. Dosage Recommendation CrCl (ml/min)<30 : Half the dosage or double dosing interval
363 Clindamycin HCl 300mg Capsule J01FF01-110-C10-01-XXX A* i) Skin and soft tissue infections, bone& joint infections
ii) Cerebral toxoplasmosis
iii) Children less than 8 years old: Treatment and prophylaxis of malaria in combination with quinine, as an alternative to doxycline		 i) ADULT: 150 - 300 mg every 6 hours; up to 450 mg every 6 hours in severe infections; Max: 1.8g/day CHILD: 3 - 6 mg/kg every 6 hours. Children weighing <10 kg should receive at least 37.5 mg every 8 hr.
ii) 600 mg 6 hourly for 6 weeks
iii) 10mg/kg twice a day, in combination with quinine. The combination to be given for 7 days
364 Clindamycin Phosphate 150mg/ml Injection J01FF01-162-P30-01-XXX A* i) Skin and soft tissue infections, bone & joint infections
ii) Cerebral toxoplasmosis		 None i) ADULT: 0.6 - 2.7 g daily (in 2 - 4 divided doses); up to 4.8 g daily; CHILD over 1 month, 20 - 40 mg/kg/day or 350 mg/m2/day in 3 - 4 divided doses
ii) 1200 mg every 6 hours for 3 weeks followed by 300 mg orally every 6 hours for another 3 weeks
365 Clobazam 10 mg Tablet N05BA09000T1001XX A* As adjunctive therapy in patients with epilepsy not adequately stabilised with their basic medication. The initial dose in adults and adolescents >15 yr should be low (5 to15mg daily), if necessary, increased gradually to a maximum daily dose of about 80mg. Doses of up to 30mg may be taken as a single dose in the evening. The initial dose in children from 3 to15 yr is normally 5mg. A maintenance dose of 0.3 to 1.0mg/kg body weight daily is usually sufficient.
366 Clobetasol Propionate 0.05% Cream D07AD01133G1001XX A Short term treatment only of more resistant dermatoses eg. psoriasis, recalcitrant eczemas, lichen planus, discoid lupus erythematosus and other conditions which do not respond satisfactorily to less potent steroids Apply sparingly once or twice daily, changing to lower potency therapy as soon as condition is controlled. For mild to moderate use maximum for 2 weeks. For moderate to severe maximum duration 4 consecutive weeks. Max: 50 g/week
367 Clobetasol Propionate 0.05% Ointment D07AD01133G5001XX A Short term treatment only of more resistant dermatoses eg. psoriasis, recalcitrant eczemas, lichen planus, discoid lupus erythematosus and other conditions which do not respond satisfactorily to less potent steroids Apply sparingly once or twice daily, changing to lower potency therapy as soon as condition is controlled. For mild to moderate use maximum for 2 weeks. For moderate to severe maximum duration 4 consecutive weeks. Max:50 g/week
368 Clobetasone Butyrate 0.05% Cream D07AB01-255-G10-01-XXX A/KK For the relief of the inflammatory and pruritic manifestations of steroid responsive dermatoses. None Apply to 1-2 times a day
369 Clobetasone Butyrate 0.05% Ointment D07AB01-255-G50-01-XX A/KK For the relief of the inflammatory and pruritic manifestations of steroid responsive dermatoses. None Apply to 1-2 times a day
370 Clodronate 800 mg Tablet M05BA02011T1011XX A* Treatment of hypercalcaemia due to malignancy 2 tablets in single or two divided doses
371 Clofazimine 100mg Capsule J04BA01-000-C10-02-XXX B i) Previously untreated leprosy patients
ii) Leprosy patients resistant to sulphones
iii) Suppression of lepra reactions		 None i) ADULT: 100 mg each other day or 50 mg daily with 100mg Dapsone & 300mg once a month with 600mg rifampicin under supervision. Maximum: 200 mg/day. CHILD: 10-14 yr: 50mg clofazimine on alternate days with 50mg dapsone & 150 mg clofazimine with 450 mg rifampicin once a month.Maximum: 100 mg/day.

ii) 100 mg daily

iii) 200-300mg usually effective. Treatment with minimum suppression dose continued for at least 6 months
372 Clofazimine 50mg Capsule J04BA01-000-C10-01-XXX B i) Previously untreated leprosy patients
ii) Leprosy patients resistant to sulphones
iii) Suppression of lepra reactions		 None i) ADULT: 100 mg each other day or 50 mg daily with 100mg Dapsone & 300mg once a month with 600mg rifampicin under supervision. Maximum: 200 mg/day. CHILD: 10-14 yr: 50mg clofazimine on alternate days with 50mg dapsone & 150 mg clofazimine with 450 mg rifampicin once a month.Maximum: 100 mg/day.

ii) 100 mg daily

iii) 200-300mg usually effective. Treatment with minimum suppression dose continued for at least 6 months
373 Clomiphene Citrate 50mg Tablet G03GB02-136-T10-01-XXX A Treatment of ovulatory failure in women desiring pregnancy None Initial: 50 mg once daily for 5 days. Increase to 100mg OD for 5 days if there is no response (commence as early as 30 days after the previous course).
374 Clomipramine HCI 25mg Tablet N06AA04110T1001XX A Depression, obsessive-compulsive disorder. Initially 10 mg daily, increased gradually as necessary to 30 - 150 mg daily in divided doses or as a single dose at bedtime; max 250 mg daily. ELDERLY initially 10 mg daily increased carefully over approximately 10 days to 30 - 75 mg daily;Child: ≥10 yr: Initially, 25 mg daily, increased gradually over 2 wk. Max: 3 mg/kg/day or 100 mg daily, whichever is smaller. Give in divided doses. Once titrated, dose may be given as a single dose at bedtime.
375 Clonazepam 0.5mg Tablet N03AE01-000-T10-01-XX B i) Epilepsy ii) Non-epileptic myoclonus None i) & ii) ADULT: Initial dose should not exceed 1.5mg/day divided into 3 doses, may be increased in increments of 0.5mg every 3 days until seizures are controlled. Maintenance dose: 3-6mg/day. Maximum: 20mg/day. CHILD up to 10 years: initial dose 0.01-0.03 mg/kg/day in 2-3 divided doses, increased by no more than 0.25-0.5mg every third day, maximum 0.2mg/kg/day. CHILD 10-16 years: initial dose 1-1.5mg/day in 2-3 divided dose, may be increased by 0.25-0.5mg every third day until individual maintenance dose of 3-6mg/day is reached.
376 Clonazepam 2mg Tablet N03AE01-000-T10-02-XX B i) Epilepsy ii) Non-epileptic myoclonus None i) & ii) ADULT: Initial dose should not exceed 1.5mg/day divided into 3 doses, may be increased in increments of 0.5mg every 3 days until seizures are controlled. Maintenance dose: 3-6mg/day. Maximum: 20mg/day. CHILD up to 10 years: initial dose 0.01-0.03 mg/kg/day in 2-3 divided doses, increased by no more than 0.25-0.5mg every third day, maximum 0.2mg/kg/day. CHILD 10-16 years: initial dose 1-1.5mg/day in 2-3 divided dose, may be increased by 0.25-0.5mg every third day until individual maintenance dose of 3-6mg/day is reached.
377 Clonidine HCl 0.025 mg Tablet N02CX02110T1001XX A Rapid opiod detoxification combination use with naltrexone Rapid detoxification in 4-5 days (use with naltrexone): 6 mcg/kg ORALLY divided in 3 doses 6 to 8 hours apart the first day, increasing to 11 mcg/kg divided in 3 doses given day two, tapering to 0.6 mcg/kg the third day. Rapid opioid detoxification for 7 days ( use with naltrexone) : 0.1 to 0.2 mg every 4 hours as needed
378 Clopidogrel 75 mg Tablet B01AC04192T1001XX A/KK Secondary prevention of atherothrombotic events in:
i) Adult patients suffering from myocardial infarction (from a few days until less than 35 days), ischaemic stroke (from 7 days until less than 6 months) or established peripheral arterial disease.
Prescribing restriction: as second/third line treatment in patients who are sensitive or intolerant to acetylsalicylic acid and/or ticlopidine).

ii) Adult patients suffering from acute coronary syndrome:
• Non-ST segment elevation acute coronary syndrome (unstable angina or non-Q-wave myocardial infarction), including patients undergoing a stent placement following percutaneous coronary intervention.
• ST segment elevation acute myocardial infarction, in combination with acetylsalicylate acid (ASA) in medically treated patients eligible for thrombolytic therapy.		 75 mg once daily
379 Clostridium Botulinum Toxin Type A 100 units M03AX01-000-P40-01-XXX A* i) Focal dystonias
ii) Hemifacial spasm
iii) Spasticity including cerebral palsy
iv) Neurogenic bladder		 20 - 200 units 3 months once
380 Clostridium Botulinum Type A toxin haemagglutinin complex 300 units/vial powder for injection M03AX01000P4003XX A* i) Focal dystonias ii) Hemifacial spasm iii) Spasticity including cerebral palsy Initially 20 U/kg divided between both calf muscles. May be titrated 10-30 U/kg up to max of not >1000 U/patient. Should only be used in children > 2 years of age. Repeat injections given not less than 3 months from previous injection.
381 Clostridium botulinum Type A toxin haemagglutinin complex 500U/vial powder for injection M03AX01000P4002XX A* i) Focal dystonias ii) Hemifacial spasm iii) Spasticity including cerebral palsy Initially 20 U/kg divided between both calf muscles. May be titrated 10-30 U/kg up to max of not >1000 U/patient. Should only be used in children > 2 years of age. Repeat injections given not less than 3 months from previous injection.
382 Clotrimazole 1% Cream D01AC01-000-G10-01-XXX B For treatment of fungal infection (eg: cutaneous candidiasis, tinea orporis, tinea cruris, tinea pedis and tinea versicolor). None Apply on affected area twice daily, optimally for 4 weeks including 2 weeks after lesions have cleared.
383 Clotrimazole 1% Ear Drop S02AA00-000-D10-02-XXX B Otomycosis; concomitant therapy with antibiotics and corticosteroid ear drops None 4 to 5 drops 3 to 4 times daily
384 Clotrimazole 1% Solution D01AC01-000-L42-01-XXX A For treatment of large lesion of fungal infection (eg: cutaneous candidiasis, tinea orporis, tinea cruris, tinea pedis and tinea versicolor). None Apply on affected area by rubbing for 2-3 times daily after cleaning. Continue treatment up to 2-4 weeks
385 Clotrimazole 500mg Vaginal Tablet G01AF02-000-S10-03-XXX B Vaginal candidiasis None 500 mg as a single one-time dose
386 Cloxacillin Sodium 125mg/5ml Suspension J01CF02-520-L80-01-XXX B Treatment of susceptible bacterial infections, notably penicillinase-producing staphylococci None Child: 50-100 mg/kg in divided doses every 6 hr
387 Cloxacillin Sodium 250mg Capsule J01CF02-520-C10-01-XXX B Treatment of susceptible bacterial infections, notably penicillinase-producing staphylococci None ADULT: 250 - 500 mg every 6 hours. Child: 50-100 mg/kg in divided doses every 6 hr.
388 Cloxacillin Sodium 250mg Injection J01CF02-520-P40-01-XXX B Treatment of susceptible bacterial infections, notably penicillinase-producing staphylococci infections None ADULT: 250 to 500 mg every 6 hours depending on type and severity of infection. CHILD less than 20 kg: 25 to 50 mg/kg/day in equally divided doses every 6 hours
389 Cloxacillin Sodium 500mg Capsule J01CF02-520-C10-02-XXX B Treatment of susceptible bacterial infections, notably penicillinase-producing staphylococci None ADULT: 250 - 500 mg every 6 hours. Child: 50-100 mg/kg in divided doses every 6 hr.
390 Cloxacillin Sodium 500mg Injection J01CF02-520-P40-02-XXX B Treatment of susceptible bacterial infections, notably penicillinase-producing staphylococci infections None ADULT: 250 to 500 mg every 6 hours depending on type and severity of infection. CHILD less than 20 kg: 25 to 50 mg/kg/day in equally divided doses every 6 hours

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